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Do you suffer with chronic pain, fatigue, anxiety or inflammation? If so then this could be of great interest to you!

Want to know what all the fuss is about?

We’ve stumbled upon something marvellous and we really want to share this with you all!
It’s called CBDa oil – totally natural, totally patented and totally award winning!


As you will recall, from my last update, I had mentioned a patient of mine, who had been in a real state and after a very brief time of using this product he has come on in leaps and bounds in almost an unprecedented fashion! I have since heard that his mother, also in a bad state of health with extensive osteoarthritis in her hips and spine has decided to try CBDa and has already found she is able to climb stairs and walk more, with far less pain than before , whilst also feeling really, really good! Just today I’ve had news from this lovely lady, who has reported that her husband (also riddled with arthritis and unable to walk or sleep without discomfort) has been able to sleep for 10 hours undisturbed! This after years of being in pain.



Taking it a step further I decided to try this product myself. Since the age of 12 I have suffered from a quite severe and unexplained daily headache syndrome – this basically means than, on a daily basis, I have a headache. Despite being thoroughly checked over, the only thing that I was ever offered was Beta Blockers, which I wasn’t keen on taking as I felt it wasn’t really getting to the route of the issue. 

I have a theory that my sub occipital muscles (the muscles around the base of the skull) are too tight, as I have an absolutely enormous occipital protuberance (the bony bit at the back of the skull) and this is what causes my headaches. Anyway – I can say with absolute certainty that after a week of taking the CBDa oil my headaches are far less noticeable and I’ve all but knocked the pain relief on the head (see what i did there?)! My partner is also finding that regular usage is helping him get through an acute bout of sciatica whilst we work on getting him recovered mechanically. 

I’m currently compiling a list of research papers (see below for peer reviewed papers and links to ‘interesting stuff’), which I’ll probably put up on my website, but needless to say, there is a lot of it – I’m just sifting through it all to ensure good quality information. 


Why 10xPURE-GOLD SUPER 1000mg over other products?
10xPURE-GOLD Super 1000 contains a minimum of 6mg of CBDa per serving…that’s over 10 times more than what might be found in most CBD products currently on the market. The oil is hydrophilic, making it’s potency stronger and allowing it to be more easily absorbed by the body. The creators of this product also go through rigorous 3rd party testing and are happy to publish their reports (see link below), which to me seems pretty kosher. 
For those of you who have taken CBD oil before, I have no doubt that it’s left a lingering and rather bitter taste in the mouth (quite literally!), but I’m pleased to say that this oil has been reinforced with peppermint, so the taste is far more palatable and pleasant.

CTFO – Documentation (myctfo.com)
 

Now for the science bit…

You probably will have heard of CBD oil, but what is CBDa?
The ‘a’ in CBDa stands for acid – when a cannabis plant grows is produces THCA and CBDA. When heated, there is a decarboxylation, creating THC and CBD. 

Now, at this point, I need to point out that with both CBD and CBDa oils, there is no worry about getting ‘stoned’ or ‘high’ because the THC has been removed – this is the bit that binds to our endocannabinoid system, which then creates these ‘states of being’ (isn’t it interesting that we have receptors for this though?!)


So why have we heard more about CBD and not so much about CBDa?
Up until recently, CBDa was found to be less stable, but all that has changed with new processes where scientists have been able to  stabilize CBDA by converting it into a methyl ester derivative called HU-580. This new compound appears to still influence the COX-2 enzyme and 5-HT receptors in the same way that CBDA does.




What are the benefits of CBDa?

* Improved mood and mental state
* Improved physical performance
* Reduced acute and chronic/neuropathic pain
* Helps greatly in the management of arthritic pain
* Improved healthy sleep regulation
* Reduced anxiety
* CBDa is showing promising signs of being effective in the treatment of conditions such as autism and certain types of epilepsy
* Reduced inflammation


Where can I get 10xPURE-GOLD SUPER 1000 CBDa? 
We now have a mini-site via our main website that will take you straight to our online store.

https://manasanctuary.co.uk/cbda-store/




Are there any side effects?
Although a small number of people have purported to have symptoms such as dry mouth, fatigue, diarrhoea and nausea, the chances of experiencing these types of symptoms remains very low.


Are there any contraindications to taking CBDa (reasons why I shouldn’t take it?)
If you are taking any medications or have any pre-existing medical conditions and are unsure then it is best to consult your GP prior to commencing. I’ve attached a link below for more reading and also a list of medications that I would just exercise a little caution with

https://medicineornot.com/what-drugs-should-not-be-taken-with-cbd/

  • Fentanyl
  • Antihistamines
  • Benzodiazepines
  • HIV Antivirals
  • Steroids
  • Macrolide Antibiotics
  • Calcium Channel Blockers
  • HMG CoA Reductase Inhibitors
  • Immune Modulators
  • Anti-arrhythmics


Why are we using an American supplier as opposed to a UK one?
Well – the fact is…the American’s have been prescribing cannabis for medicinal purposes for some years now, making them ahead of the game when it comes to their cannabis based research compared to the UK. As far as I’m aware and currently in the UK, there’s no match for this in our market. I have spoken to CTFO and they have assured me that they have a ‘to do list’ and at the top is converting currencies to make their site more user friendly as their product goes global. 

I’m trying to place my order, but I can’t find an option for the UK…
Not to worry – just remember to click on the flag icon in the top right of your screen to select your country before placing your order.




Research?

https://www.openaccessgovernment.org/cbd-oil-for-pain-what-the-research-shows/113198/

Chronic pain: a review of its epidemiology and associated factors in population-based studies (nih.gov)

Chronic Pain: Where the Body Meets the Brain (nih.gov)

Cannabis, a complex plant: different compounds and different effects on individuals (nih.gov)

An introduction to the endogenous cannabinoid system (nih.gov)

An introduction to the endogenous cannabinoid system (nih.gov)


Cannabinoids and Epilepsy (nih.gov)

The effects of cannabidiol and analgesic expectancies on experimental pain reactivity in healthy adults: A balanced placebo design trial. – PsycNET (apa.org)

Providing chronic pain management in the “Fifth Vital Sign” Era: Historical and treatment perspectives on a modern-day medical dilemma (nih.gov)

Therapeutic Effects of Cannabis and Cannabinoids – The Health Effects of Cannabis and Cannabinoids – NCBI Bookshelf (nih.gov)

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (nih.gov)

Neuropathic pain (nih.gov)

Treatment Considerations for Patients With Neuropathic Pain and Other Medical Comorbidities (nih.gov)

The Most Common Side Effects Experienced by Patients Were Receiving First Cycle of Chemotherapy (nih.gov)

An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics – Journal of Pain and Symptom Management (jpsmjournal.com)

Inflammatory responses and inflammation-associated diseases in organs (nih.gov)

Chronic inflammation in the etiology of disease across the life span (nih.gov)

Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis (nih.gov)

Pain as a disease: an overview (nih.gov)

What has serotonin to do with depression? (nih.gov)

Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age (nih.gov)

Cannabidiol in humans-the quest for therapeutic targets – PubMed (nih.gov)

Cannabinoids in the management of difficult to treat pain (nih.gov)

A Cross-Sectional Study of Cannabidiol Users (nih.gov)

Cannabis and Pain: A Clinical Review (nih.gov)

Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis – PubMed (nih.gov)

The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain – PubMed (nih.gov)

Endocannabinoid system: An overview of its potential in current medical practice – PubMed (nih.gov)

Cannabis+improves+symptoms+of+ADHD.pdf (squarespace.com)

Children with Autism Pilot Study | Cannformatics

Endocannabinoid+System+as+Novel+Therapeutic+Target+for+Autism+Treatment.pdf (squarespace.com)

The+Endocannabinoid+System+and+Plant-Derived+Cannabinoids+in+Diabetes+and+Diabetic+Complications.pdf (squarespace.com)

CANNABIS+IN+THE+MANAGEMENT+AND+TREATMENT+OF+SEIZURES+AND+EPILEPSY-+A+SCIENTIFIC+REVIEW.pdf (squarespace.com)

Endocannabinoid+Signaling+Regulates+Sleep+Stability.pdf (squarespace.com)

Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors – PubMed (nih.gov)

Chronic Treatment with Cannabidiolic Acid (CBDA) Reduces Thermal Pain Sensitivity in Male Mice and Rescues the Hyperalgesia in a Mouse Model of Rett Syndrome – ScienceDirect



Links to interesting stuff…
CBDA Oil What Is It? | Cannabidiolic Acid Benefits | Synchronicity Blog (synchronicityhempoil.com)
CBDA vs CBD: The Benefits of CBDA – Learning CBD Oil
CBD Oil for Pain: Does It Work, Arthritis, Cancer & More (healthline.com)
Research shows pain relieving effects of CBD — ScienceDaily
CBD oil and cancer: What the research shows (openaccessgovernment.org)
What is CBDA (Cannabidiolic Acid) & what are the benefits of this cannabinoid? (leafly.com)
CBD Oil for Pain: Effects, Research, and Benefits (handpickedcbd.com)
Pain Archives – CBD Incubator
New Research Shows Pain-Relieving Effects of CBD | Syracuse University News
Research Shows Pain Relieving Effects of CBD – Neuroscience News
Top CBDA (Cannabidiolic Acid) Questions Answered by CBD Science
Studies about CBD Oil & Pain [Research Simplified] (greenthevoteok.com)
CBD oil for anxiety: research, benefits and dosage suggestions (netdoctor.co.uk)
CBD for Osteoarthritis – July 2021 – CBD Clinicals
Best CBD Oil for Gastritis – July 2021 – CBD Clinicals
Does CBD Oil Really Help Treat Arthritis Pain? (rheumatoidarthritis.org)
CBD oil: Effects and side effects (medicalnewstoday.com)
What is CBDA? Everything You Need to Know About CBDA vs CBD (medicalmarijuanainc.com)
What Drugs Should Not Be Taken With CBD? [Precautions to Take] – Medicine or Not?

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